A Multimodal Approach to Acute Pain Management: the Role of IV NSAIDs

Raymond S. Sinatra, MD, PhD

Professor Emeritus of Anesthesiology and Acute Pain Management
Yale School of Medicine

Pain Pathway and IV NSAIDs Part 1 of 5—Pain Pathway
and IV NSAIDs
(10 minutes)		 Rationale for Caldolor Use Part 4 of 5—Rationale for Caldolor Use
(9 minutes)
Preemptive Analgesia Part 2 of 5—Preemptive Analgesia
(4 minutes)		 Caldolor Safety Summary Part 5 of 5—Caldolor Safety Summary
(4 minutes)
Orthopedic Study: Less Pain, Less Morphines Part 3 of 5—Orthopedic Study:
Less Pain, Less Morphine
(7 minutes)
Development of this site is in the support
of Caldolor® (ibuprofen) Injection

INDICATIONS FOR CALDOLOR
CALDOLOR is indicated in adults for the management of mild to moderate pain, management of moderate to severe pain as an adjunct to opioid analgesics, and reduction of fever.

WARNING: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS

Cardiovascular Risk

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of serious cardiovascular (CV) thrombotic events, myocardial infarction, and stroke, which can be fatal. Risk may increase with duration of use.
  • Caldolor is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.

    • Gastrointestinal Risk

  • NSAIDs increase the risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Events can occur at any time without warning symptoms. Elderly patients are at greater risk.

    • IMPORTANT SAFETY INFORMATION
    CALDOLOR should be used with caution in patients with congestive heart failure, kidney impairment, at risk of blood clots, and in those who have a history of ulcers or gastrointestinal bleeding. When used in such patients, attention to using the lowest effective dose for the shortest time period is important to reduce the risk of serious adverse events. Ibuprofen has been associated with high blood pressure, serious skin reactions, and serious allergic reactions.

    The most common adverse events reported in the controlled clinical trials were nausea, flatulence, vomiting, and headache.

    Please see full Prescribing Information, including Boxed Warning.



    To learn more about Caldolor® (ibuprofen) Injection, visit Caldolor.com